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KMID : 0359920080270050622
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Korean Journal of Nephrology
2008 Volume.27 No. 5 p.622 ~ p.625
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A Case of Rapidly Progressive Glomerulonephritis in a Hepatitis B Virus Carrier Successfully Treated with High dose Immunosuppressive Therapy and Prophylactic Lamivudine
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Lee Jung-Eun
Park Jung-Tak
Kim Beom-Seok
Lee Ho-Yung
Han Dae-Suk
Choi Kyu-Hun
Lee Jung-Myung
Jeong Hyeun-Joo
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Abstract
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A 35-year-old man, previously hepatitis B surface antigen (HBsAg) carrier, presented with gross hematuria and heavy proteinuria that he had been suffering from for 1 month. Serum creatinine was 4.4 mg/dL. Renal biopsy showed pauci-immune crescentic glomerulonephritis. He received plasmapheresis and was treated with high-dose steroids and cyclophosphamide. Lamivudine was started for the prevention of hepatitis B virus (HBV) activation. Serum creatinine and proteinuria were ameliorated one week after the treatment. There was no sign of HBV activation after six months of treatment. We report a case of rapidly progressive glomerulonephritis in a HBV carrier successfully treated with high dose immunosuppressive therapy and prophylactic lamivudine.
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KEYWORD
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Lamivudine, Hepatitis B Virus, Rapidly Progressive Glomerulonephritis
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